CAS 480-41-1

 naringenin Appearance

Naringenin Details

Chemical Name: Naringenin

Another Name: Citrus Grandis (Grapefruit) peel extract

CAS No.: 480-41-1

Molecular Formula: C15H12O5

Formula Weight: 272.25

Naringenin Typical Properties

Item Specification
Product Name Grapefruit Peel Naringenin Extract
Latin Name Citrus grandis L.
Appearance: White Crystaline
Specification: 98%
Part Used: Peel
Melt Point 247~250℃
CAS NO. 480-41-1
Molecular Weight  272.25
Molecular Formular C15H12O5
Test Method HPLC


Naringenin Application

1. Alzheimer’s Disease

Naringenin is being researched as a potential treatment for Alzheimer’s Disease. Naringenin has been demonstrated to improve memory and reduce amyloid and tau proteins in a study using a mouse model of Alzheimer’s Disease.

2. Antibacterial, antifungal, and antiviral

There is  evidence of antibacterial effects on H. pylori. Naringenin has also been shown to reduce hepatitis C virus production by infected hepatocytes (liver cells) in cell culture. This seems to be secondary to naringenin’s ability to inhibit the secretion of very-low-density lipoprotein by the cells. The antiviral effects of naringenin are currently under clinical investigation.  Reports of antiviral effects on polioviruses HSV-1 and HSV-2 have also been made, though replication of the viruses has not been inhibited.

3. Antioxidant

Naringenin has been shown to have significant antioxidant properties.

Naringenin has also been shown to reduce oxidative damage to DNA in vitro and in animal studies.

4. Anti-injury effect
Injury refers to the destruction of the tissue caused by various trauma factors (such as severe infection, trauma, shock, toxic heavy metals, etc.) and its local and systemic reactions. Naringenin has a protective effect on lead-induced damage and provides a research direction for the treatment of damage caused by toxic heavy metals. An acute lung injury (ALI) model was established by lipopolysaccharide (LPS) induction. Different doses of naringenin were injected intraperitoneally. The correlation of factors in bronchoalveolar lavage fluid showed that naringenin significantly inhibited TNF-α and TGF-β1. Up-regulation of MMP-9 and TIMP-1 levels decreased the levels of malondialdehyde and hydroxyproline in the lungs, increased the activity of SOD, GSH-Px, and HO-1, indicating that naringenin can effectively protect and treat ALI. It provides a new idea for clinical treatment of lung injury.

5. Lowering blood fat
Hyperlipidemia is mainly caused by high levels of cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDLC) in plasma. It is a common disease that threatens human health and its incidence is increasing year by year. . Although statins and fibrates are effective, they have many side effects. Therefore, people have shown great interest in the efficacy of traditional Chinese medicine in reducing blood fat. Studies have found that flavonoids such as naringenin can reduce the concentration of CH and TG in the blood by inhibiting apolipoprotein B secreted by the liver, thereby achieving the effect of lowering blood fat. Naringenin can also inhibit HMGCoA reductase activity, reduce blood lipid levels in hyperlipidemia rats, improve lipid metabolism in hyperlipidemia rats, and inhibit the formation of atherosclerosis and fatty liver.

Naringenin Packaging and Shipping

Package: 25kg/drum.

Naringenin in Storage

Stored in the dry and ventilated inside storeroom, prevent direct sunlight, slightly pile and put down.

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